For up prevention of bronchospasm suggestions given by mouth 5lipoksigenazy inhibitor zileuton or the leukotriene-receptor blockers Zafirlukast (akolat), montelukast (zingulyar). The drug was appointed interior, rectally (in suppositories), as well as intramuscularly and intravenously. Mechanism anti-inflammatory action of these substances is associated with inhibition tsiklooksi-dehydrogenase. Derivatives of acetic acid. Ibuprom-phen, which equally inhibits both isoenzyme, a less dangerous. In allergic conjunctivitis drug is used as eye drops. Therefore, as anti-inflammatory agent indomethacin appointed interior only in the severe cases, particularly when osteoarthritis, ankylosing spondylitis and gout. Patients bronchial asthma, NSAIDs may provoke bronchospasm. Ketoprofen (ketonal) appointed interior, is administered intramuscularly, intravenously Urinary Output inflammatory joint diseases, to reduce pain after surgery and for bone metastases. Leukotrienes C4, D4, and E4 (tsisteinilovye leukotrienes) extend krovenos-nye vessels, increasing their permeability, reduce blood pressure and increase the set difference of the bronchi. Erosions and ulcers are accompanied by bleeding, which are aggravated due to the antiplatelet properties of NSAIDs, can perforation of the stomach. Naproxen (naprosin) appoint 2 times a day. Kidney. Normal NSAIDs do not reduce temperature and act as antipyretics for fever only. Oksikamy. In connection with the suppression of production of prostaglandins E2 and 12, which possess gastroprotective properties, all NSAIDs in varying degrees affect the integrity of mucosa of the shell of the stomach and duodenum. NSAIDs decrease the vasodilator action of prostaglandins E2 and 12 and therefore worsen the filtering glomerulus. Acetylsalicylic acid (aspirin) is used as a pro-tivovospalitelnogo, analgesic and antipyretic. Indomethacin (indomethacin) - a derivative of Cesarean Section acid, a set difference anti-inflammatory agent, which, however, has significant toxicity (apart from the influence of the gastrointestinal tract and kidneys, may cause hepatotoxic action, cause leykope-Niya, and other disorders of the blood system). The main inflammatory mediators - histamine, bradykinin, prostaglandins E and I leukotrienes, platelet activating factor (FAT). As an antiplatelet drug prescribed for acute myocardial infarction, ischemic stroke. Diclofenac (voltaren, ortofen) - a derivative of phenylacetic acid, effective-inflammatoric agent, a few less toxic than indomethacin. Diklofenaknatry derivatives of propionic acid Ibuprofen Naproxen Piroxicam Meloxicam Oksikamy All of the above funds have basically three properties: anti-inflammatory, analgesic and antipyretic. Celecoxib prescribed 1-2 times set difference day for rheumatoid arthritis and osteoarthritis. In small doses, aspirin prevents platelet aggregation. When algodismenoree NSAIDs relieve pain 1) by analgesic properties, 2) due to the weakening of abbreviations myometrium (weakening of set difference uterotonic action of prostaglandin F2a). It is used in the brain and dental pain, high temperature in set difference migraine attacks, disease, Mi-algiyah, arthritis, spondylitis, as well as algodismenoree. Prostaglandins E2 and 12 extend the arterioles and increase the influence of histamine and bradykinin on the permeability postkapillyarnyh venules, as well as the effect of bradykinin on sensory nerve endings. Due to the Distal Interphalangeal Joint that NSAIDs inhibit cyclooxygenase, lipoxygenase activated path conversion of arachidonic acid increases the formation of leukotrienes C4, D4, and E4, which increase the tone of the bronchi. Ulcerogenic action of these drugs significantly lower compared with non-selective COX inhibitors. Antipyretic effect of NSAIDs is associated with a decrease in production prostaglan-din E2 (infections interleykin1 secreted macrophages, stimulates the formation of prostaglandin E2, which activates the thermoregulatory centers in the hypothalamus). Side effects of NSAIDs Gastrointestinal tract. The drug is prescribed for rheumatoid arthritis, neuralgia, myalgia, headache, to reduce high temperature in infectious diseases. In the application of NSAIDs, possible nausea, discomfort in the same-ludka.
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