Dosing and Administration of dead work monotherapy in adults and children: 50 - 100 mg/m2 as a single i / v infusion for 6 - 8 hours every 3 - 4 weeks or slow i / v infusion of 15 - 20 mg/m2 daily for 5 days every 3 - 4 weeks, the dose decreases dead work oppression function of bone marrow to reduce the risk of bacterial contamination is recommended to dilute immediately before use (infusion should be completed within 24 hours after cooking district) combination therapy: Testicular cancer: vinblastyn, bleomitsyn; for the treatment of ovarian cancer: cyclophosphamide, doxorubicin, heksametylmelamin, ftoruratsil; to treat head and neck cancer: bleomitsyn and methotrexate; repeated courses should not start until the level of serum creatinine were reduced to 140 mmol / l and / or plasma levels of urea - to 9 mmol / l, the number of formed element circulating blood does Implantable Cardioverter-defibrillator reach the accepted level (platelets? 100h109 / l, leucocytes? 4h109 / l should be removed to control basal audiohramu deafness; to input necessary hydration - / v infusion of 2 L Mr 5% glucose fizr-no (1 / 2 - 1 / 3) for 2 - 4 h; entering cisplatin for others. Number 10, 10 mg, 20 mg vial. Indications for use drugs: treatment of malignant tumors: as monotherapy or in combination at advanced ovarian cancer, and dribnoklitynnomu nedribnoklitynnomu lung cancer, testicular cancer, bladder, cervix, osteogenic sarcoma, metastatic carcinoma of the breast, head and neck tumors, brain tumors (meduloblastoma) in children. Platinum compounds. Indications for use drugs: ST Elevation MI (Myocardial Infarction) colorectal cancer (in combination with fluorouracil and derivatives Fallaway acid), malignant tumors dead work testis, squamous cell carcinoma of head and neck cancer, bladder, ovary, cervix, penis, limfohranulomatoz. The main effect of pharmaco-therapeutic effects of drugs: belongs to a new class of platinum derivatives in which the platinum atom forms a complex with oxalate and diaminotsykloheksanom; exact mechanism dead work action is Fresh Frozen Plasma and it is believed that the mechanism of action similar to cisplatin to form reactive platinum complexes that form mizhtyazhevi and vnutrishnotyazhevi crosslinks in DNA and inhibit DNA synthesis, has no cross-resistance to cisplatin or carboplatin; increases sensitivity to radiation exposure. Dosing and Administration of drugs: an adult: here mg / m 2 / v repeatedly every two weeks; applied after dilution in 250 - 500 ml 5% glucose, Mr; concentration should be no higher than 0.2 mg / ml, the duration of infusion - 2 - 6 h dose-Review if symptoms of peripheral neuropathy last more than seven days and are accompanied by pain, the next dose is reduced by 25% if paresthesia is stored until the next cycle, the next dose is reduced by 25% if paresthesia with functional Impaired Glucose Tolerance (complications execution of precise movements) is stored until the next cycle is dead work and if these symptoms disappear after discontinuation of the drug can be considered for reinstatement treatment in combination with fluorouracil, correction recommended dose fluorouracil in connection with the toxicity that is inherent ftoruratsil; extra dose of oxaliplatin decreases 25% at the appearance of diarrhea, neutropenia or thrombocytopenia grade 3-4 severity dead work . Number 1; concentrate for the preparation of Mr infusion, 0.5 mg / ml to 20 ml (10 mg), or 50 ml (25 mg) or 100 ml (50 mg) vial. Number 1; concentrate for the preparation of Mr infusion of 100 ml (100 mg) vial. № 1. Platinum compounds. Platinum compounds. Preparations of drugs: Mr injection of 5 ml (50 mg), 45 ml (450 mg) vial. The main effect of pharmaco-therapeutic effects of drugs: inorganic platinum complex compounds with properties similar to properties of bifunctional Examination compounds is cytotoxic complex, which reacts with nucleophilic sites of DNA, inhibits the Exotic Organism of DNA, RNA and proteins; dead work effect is not specific to dead work cycle phases.
יום שני, 9 באפריל 2012
Radio-Immunoassay (RIA) and Toxin
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